Allegra non sedating antihistamines

23-Jan-2018 01:08 by 2 Comments

Allegra non sedating antihistamines

For analysis of the efficacy, only double-blind, placebo-controlled studies were selected, whereas uncontrolled studies were excluded.Data on study drug, doses, study design, treatment duration, subtype of urticaria being treated, number of patients, and main parameter of efficacy, were collected.

The affinity for the H1 receptor is 3 and 6 times higher than for cetirizine and fexofenadine, respectively [A literature search of Pub Med/MEDLINE looking specifically at the studies that investigated the effects of increased doses of NSAHs in patients with all subtypes of CU was conducted.Efficacy of increased doses of nonsedating antihistamines in patients with chronic urticaria. *Fexofenadine 120 mg vs Fexofenadine 240 mg p = 0.01, ¶ Fexofenadine 120 mg vs Rupatadine 20 mg p = 0.0001, ♦ Fexofenadine 240 mg vs Rupatadine 20 mg p = 0.03.B) According to percentage of symptom-free patients.Urticaria and angioedema lasting more than 6 weeks have been designated as chronic urticaria (CU).It encompasses two major subtypes: chronic spontaneous urticaria (CSU) (previously known as chronic idiopathic urticaria) (CIU) and chronic inducible urticaria.♣ Levocetirizine 10 mg vs Bilastine 80 mg p = 0.01.

According to current recommendations, patients with CU who do not respond to licensed doses of NSAHs should be switched to higher doses in order to obtain a better disease control.♦ Desloratadine 10 mg vs Bilastine 80 mg p = 0.002.♠ Desloratadine 20 mg vs Bilastine 40 mg, Desloratadine 20 mg vs Bilastine 80 mg, Levocetirizine 10 mg vs Bilastine 40 mg p = 0.02.When available, efficacy data were pooled from different studies that utilized the same drug dose.The proportions of patients responding to the therapy were compared using the Fisher’s exact test with a significance level of p Twelve studies that investigated the effects of higher doses of NSAHs were identified in this search.Among those, 3 papers dealing with the treatment of patients with CSU were excluded from analysis because of their open design, 2 employing cetirizine and one that utilized ebastine [].

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