Depressed dating site
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who records the person's current circumstances, biographical history, current symptoms, and family history.The broad clinical aim is to formulate the relevant biological, psychological, and social factors that may be impacting on the individual's mood.
The monoamine theory, derived from the efficacy of monoaminergic drugs in treating depression, was the dominant theory until recently.One proposed explanation for the therapeutic lag, and further support for the deficiency of monoamines, is a desensitization of self-inhibition in raphe nuclei by the increased serotonin mediated by antidepressants.However, disinhibition of the dorsal raphe has been proposed to occur as a result of decreased serotonergic activity in tryptophan depletion, resulting in a depressed state mediated by increased serotonin.Depression is also associated with a 1.5- to 2-fold increased risk of cardiovascular disease, independent of other known risk factors, and is itself linked directly or indirectly to risk factors such as smoking and obesity.People with major depression are less likely to follow medical recommendations for treating and preventing cardiovascular disorders, which further increases their risk of medical complications.The theory postulates that insufficient activity of monoamine neurotransmitters is the primary cause of depression.
Evidence for the monoamine theory comes from multiple areas.
However, this abnormality is not adequate as a diagnosis tool, because its sensitivity is only 44%.
Theories unifying neuroimaging findings have been proposed.
Childhood trauma also correlates with severity of depression, lack of response to treatment and length of illness.
However, some are more susceptible to developing mental illness such as depression after trauma, and various genes have been suggested to control susceptibility.
The 1990–92 National Comorbidity Survey (US) reports that half of those with major depression also have lifetime anxiety and its associated disorders such as generalized anxiety disorder. One or more pain symptoms are present in 65% of depressed patients, and anywhere from 5 to 85% of patients with pain will be suffering from depression, depending on the setting; there is a lower prevalence in general practice, and higher in specialty clinics.